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Burning the candle at both ends for a week may take an even bigger toll than you thought.

Researchers at the University of Wisconsin-Madison have found that five nights of restricted sleep — four hours a night — affect the brain in a way similar to that seen after acute total sleep deprivation.

The new study in rats, appearing in the current online edition of the Proceedings of the National Academy of Sciences, adds to the growing evidence scientists are accumulating about the negative effects of restricted sleep for both the brain and the body.

“There’s a huge amount of interest in sleep restriction in the field today,” says Dr. Chiara Cirelli, associate professor of psychiatry at the School of Medicine and Public Health, who led the research.

Many people are sleep restricted, either because they have to or because they choose to be, she says.

“Instead of going to bed when they are tired, like they should, people watch TV and want to have an active social life,” she says. “People count on catching up on their sleep on the weekends, but it may not be enough.”

This “casual” lack of sleep can be harmful.

“Even relatively mild sleep restriction for several nights can affect an individual’s ability to perform cognitive tasks,” Cirelli says. “For instance, recent studies in humans have shown that 5 days with only 4 h of sleep/night result in cumulative deficits in vigilance and cognition, and these deficits do not fully recover after one night of sleep, even if 10 hours in bed are allowed. Sleep restriction can also increase resistance to insulin, leading to a risk of diabetes.”

Cirelli and her team kept rats awake 20 hours a day over five days while continuously recording the animals’ brain waves with a sophisticated EEG as they were asleep and awake. The EEGs measured slow wave activity (SWA), the best marker of an individual’s need to sleep as well as the intensity of sleep that follows a period of wakefulness.

“Slow-wave activity reflects the fact that sleep is regulated by homeostasis: in general, the longer we stay awake, the higher is SWA in the subsequent sleep. We knew that this was true after acute total sleep deprivation (for instance when we stay up all night); now we found that this is also true after chronic sleep restriction. ” Cirelli notes..

According to the rat cumulative SWA measures, the sleep restriction produced intense recovery sleep following each wake cycle, with both longer and deeper sleep. The more effective the researchers were in keeping the animals awake during those 20 hours, the larger the sleep rebound they saw during the following four hours.

“It was an indirect but powerful indication of how sleepy the animals actually were,” Cirelli says.

Even when the animals seemed awake and were moving around, heightened SWA was evident in their “wake” EEG.

“Monitoring SWA levels during waking time is very important in understanding the whole picture,” she says. “High SWA levels during periods of both sleeping and waking signal that you need to go to sleep.”

The researchers also found that SWA levels were different in different areas of the brain, and they speculate that this may depend on what parts of the brain had been used during the waking period.

Knowing that sleep restriction evokes the same brain response as sleep deprivation will help scientists better understand the harmful effects of sleep disturbances, says Cirelli.

“Scientists have learned much from 40 years of studies on total sleep deprivation, she says. “Now we know we can apply the lessons we learned from acute sleep deprivation to chronic sleep restriction, which is very relevant to people’s lives today.”

Improved drug coverage under Medicare Part D has led to an increase in the use of antibiotics by seniors, particularly of brand-name and more expensive drugs, according to a University of Pittsburgh Graduate School of Public Health study. Published in the Aug. 23 issue of Archives of Internal Medicine and the first to explore spending on antibiotics under Medicare Part D, the study suggests recent changes in drug coverage improved the use of antibiotics for pneumonia, but could lead to unnecessary spending on expensive broad-spectrum antibiotics and the overuse of inappropriate antibiotics.

“Overuse of antibiotics is a common and important problem that can lead to medical complications and drug resistance,” said the study’s lead author, Yuting Zhang, Ph.D., assistant professor of Health economics at the University of Pittsburgh Graduate School of Public Health. “One of the key questions we sought to answer with our study is how improved prescription drug coverage under Part D affects the usage of these drugs.”

The study included more than 35,000 Medicare beneficiaries and compared their use of antibiotics two years before and after the implementation of Medicare Part D, which reduced out-of-pocket drug spending between 13 and 23 percent. They found that antibiotic use increased most among beneficiaries who lacked drug coverage prior to enrolling in Medicare Part D. Beneficiaries who previously had limited drug coverage also were more likely to fill prescriptions for antibiotics after enrolling in Part D. The largest increases were found in the use of broad-spectrum, newer and more expensive antibiotics.

Researchers also noted that the use of antibiotic treatment for pneumonia tripled among those who previously lacked drug coverage, which they say is encouraging given the high mortality associated with community-acquired pneumonia among the elderly. However, they also found increases in antibiotic use for other acute respiratory tract infections (sinusitis, pharyngitis, bronchitis and non-specific upper respiratory tract infection) for which antibiotics are generally not indicated.

“When drug coverage is generous, people are more likely to request and fill prescriptions for antibiotics, which may lead to misuse,” said Dr. Zhang. “Although many interventions have helped curb antibiotic prescribing for acute respiratory tract infections and other conditions, our study indicates there may still be substantial room for improvement through education and changes in reimbursement practices to reduce inappropriate use of these drugs.”

A nanometer is equal to one-billionth of a meter or roughly one-12,000th the thickness of the average person's hair.

South Korea's Korea Advanced Institute of Science and Technology (KAIST), has developed a flash memory cell that can be built into a semiconductor chip that is just 8 nanometers.

The result –

"A fully developed tera-level NAND flash memory can hold 500,000 audio songs in an MP3 file format or record 1,250 DVD films and 1 million high resolution photos within a space equal to that of a person's fingernail."

That's an awful lot of information in an itty bitty living space.

Efforts are being made to transfer the technology to the civilian sector.

What would you do with a flash drive that small that could hold that much?

For years Alzheimer’s disease has been both baffling to scientists, and an on-going heartbreak to those who have loved ones affected by the condition. Now it seems a test of spinal-fluid can expose a propensity toward Alzheimer’s for people suffering memory loss.  Memory loss can be caused by many things. Stroke, stress, depression or certain metabolic conditions, can all lead to forgetfulness. But now, when such a condition appears, an accurate test which will predict the likelihood of Alzheimer’s is available. And a question, would you want to know?

Mass Device is telling us, HealthNewsReview.org gave Gina Kolata’s front-page New York Times story touting spinal taps to predict Alzheimer’s disease a two-star rating – out of five. Chief complaint: its 100 accuracy claim ignored the tests “specificity” problem. Over a third of people told they were on the road to dementia didn’t develop the disease. Read more…
Huffington Post reports, Doctors can’t tell if Leif Utoft Bollesen’s mild memory loss will remain an annoyance or worsen, but experimental checks of the Minnesota man’s aging brain may offer clues.
Read more…
Brain Today says, Researchers have devised what seems to be a highly accurate test to identify the signature proteins of Alzheimer’s disease in spinal fluid. In a publication about the test in this months Archives of Neurology, the test showed perfect accuracy in patients known to have Alzheimer’s disease.

We've all seen the heartbreaking photos of oil-drenched whales, dolphins, seals and other sunlit wildlife affected by the Deepwater Horizon spill, but few of us are privy to a part of the ocean most affected worst: a massive community of living creatures living thousands of feet below the surface, known as the deep scattering layer (DSL).

Mother Jones writer Julia Whitty was tracking the DSL offshore with ecologists from Oregon State University, when the well exploded 4,400 miles away. Shooting thousands of feet below the surface, the oil dispersed through the mesopelagic stratosphere, for which 80% of the DSL dwells. Suddenly, Whitty's original story on technology to explore the DSL would take a turn a drastic turn for the worse.

The DSL is an incredibly diverse body of organisms upon which these whales, dolphins, seals and turtles survive. They thrive in dark ocean layers by day, and float towards the surface by night. Discovered by hydrographers in the 1920's, the DSL accounts for 80% of all the biomass located in the mesopelagic zone, Whitty writes.

Before the spill, Whitty says the DSL's rich biodiversity made it the "last great resource to be exploited." Ironically, BP beat the fisherman to the chase when it set out to drill at "unprecedented depths [without the] extreme safety equipment needed to stave off disaster," Whitty writes.

With the oil well that had been spewing into the Gulf of Mexico plugged from the top and BP PLC and federal officials pondering whether the final plug, or "bottom kill," is needed, local officials fear national disengagement from what remains a crisis of unknown proportions.

Meanwhile, bad weather delayed work on the relief well being drilled into next week.

"This is going to be a long-term situation," Jefferson Parish Council Chairman John Young said. "I think it's way too early for the federal government have a 'mission accomplished' type of attitude."

Work on the final kill to the well has been postponed by bad weather blowing through the region. Crews drilling relief wells to the gusher have stopped their work, and will need about four days to finish once the weather passes, retired Coast Guard Adm. Thad Allen said Wednesday.

Allen, the administration's point man on the spill, said the well may not need to have heavy mud and cement pumped into it from deep underground after all. He said testing still needs to be done on the well before a final decision is made.

BP and the federal government will check to see whether the cement pumped in through the top went down into the reservoir, came back up and plugged the space between the inner piping and the outer casing. If so, the bottom kill might not be necessary.

"We think it's a low probability event, but we can't rule it out," Allen said.

I’m proud to present this independent research project by our summer intern Mike Liu.  Mike looked at his home state of California, the recent Bell salary scandal and the need for transparency at a local level.  -  Nicko Margolies

When I first heard about the exorbitant salaries of top officials in Bell, California, my initial thoughts concerned college, not politics.

Last year I participated in student government as a freshman Senate mentee, working closely with student Senators in order to better understand university governance.

Though I obtained firsthand insight into effecting change on campus, many mentees and I left incredibly disillusioned by the lack of transparency and accountability in student government.

Both new and experienced Senators missed mandatory meetings on a whim. Furthermore, attendance at Senate committee meetings was painfully sparse: Senators often found themselves struggling to establish quorum, even when student organizations’ budgets were on the line. This was particularly troubling, considering Senator salaries (compensation many students didn’t even know about) were based on nominal committee leadership and participation.

After a controversial and unproductive year, a new batch of Senators were elected and sworn in, leaving many unaddressed problems destined for repetition.

Reading the LA Times investigation, I couldn’t believe the striking similarities between the Bell fiasco and what I had seen on campus.

"GlaxoSmithKline and Valeant got a solid endorsement for their new epilepsy drug Potiga (ezogabine) from the FDA's panel of experts, putting them on track to a likely approval. The experts unanimously agreed that the drug would benefit epilepsy patients whose meds couldn't stop seizures. And they agreed that careful monitoring would flag patients who experience an inability to urinate while taking the drug."

If you have a hard drive from Seagate you will wonder how it works and what can be done to restore the files if there is any problem with it. When you need data recovery hard drive, Seagate has what you need to help you with a multitude of problems, one of which includes seagate data recovery for all models of their hard drives. These problems can be generally solved by an expert in hard drive recovery data who knows how to recover data from all types of hard drive models from Seagate. Often when you take your data to a disk failed computer expert, the quickest solution is to replace the hard drive failed components. The most typical components failed on Seagate disk data are the engine and drive read / write heads. These can be replaced quickly by sending it back into its path. Data recovery does not work on all models of disk drives for data, but depending on the severity of the problem, a hard drive recovery expert will be able to recover your important data that you may have lost over the issue, or simply do not have access to because of problems with your data disk. Got out of your hard drive problem and got hold of your loan mortgages? Check online for perfect loan modification program.

Even though communication medium has reduced to email and phone conversation, there are many people who like to experience the thrill of hand written letters. Handwritten letters of great leaders are preserved in museums as treasures. Also, reading habit is a much essential habit to be cultivated by everyone and still magazines and journals are delivered to destinations only through postal service. So it very much essential to have mailboxes in front of your living place. If you are a lover of modern things then go with contemporary mailboxes  as they are available with wide range of colors and styles. In US, the mailboxes used in residencies and offices should meet certain criteria provided by USPS, the US postal service and bobi mailbox, a product from a Finnish  company has recently got approved by USPS. The bobi mailbox was founded by two brothers in the year 1991 in a small town in Finland. From then, this type of mailbox by the name Bobi is found available in all parts of the world. The bobi mailboxes are made of steel material and are available in different colors like red, black and silver. These mailboxes are known for their slim nature and therefore they do not occupy much space.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       

The bathroom lighting is a good way to give your bathroom a whole new cozy looks and comfort. A readiness for immediate illumination adds style and sophistication. The modern bathrooms have many functions such as countertops, sinks, bathtubs, cabinets and mirrors. You can decorate the bathroom giving it a unique, fresh look with good lighting and adequate wall colors. Here are some tips for better vanity lighting:

• The windows should always be well ventilated with mirrored glass.
• To increase the visual space, enhance the lighting of the bathroom and make sense of hygiene, the colors of the environment should always be clear, preferably use white.
• White light bulbs are the most suitable for this environment.
• The game of various lights on the mirror in addition to preventing various shades turns out to be an element of decoration.
• Avoid using dark box, curtains and bathroom lighting fixtures that obstruct the toilet.
• Decorate your bathroom with light and delicate objects that match the color of the tiles.
• For the lights to be perfect, remember that it must be practical and functional. The light sources should be placed preferably on the sides of the bathroom mirror to prevent shadows on the face.

As the US aircraft carrier USS George Washington sailed through the waters of the South China Sea, foreign media floated the possibility that China is speeding up construction of its aircraft carrier and anti-aircraft carrier missile bases.

According to AP, China is developing a carrier-killing missile called the Dong Feng 21D. The anti-carrier missile could be launched from land with enough accuracy to penetrate the defenses of even the most advanced moving aircraft carrier at a distance of more than 1,500 km.

It said the US' virtually invincible carrier fleet has long enforced its dominance of the high seas, but China may soon put an end to that.

And in an article headlined "Chinese ready to kill US Navy carriers?" the US-based website worldnetdaily.com said China has built, tested and is on schedule to deploy a missile next year that is designed to destroy a US carrier.

The Ministry of National Defence of China did not confirm the report.

The US Navy deploys 11 supercarrier battleships around the globe. Each modern US nuclear aircraft carrier, with two reactors, can carry more than 6,000 service personnel and more than 80 aircraft. They are nearly 335 meters long but fast and maneuverable.

US defense analysts acknowledge that the Dong Feng 21D, could be a game-changer, AP reported.

Experts said US aircraft carriers are long-term and real threats to China's national security.

Su Hao, director of the Center for Asia-Pacific Region at China Foreign Affairs University, told China Daily that US aircraft carriers frequently approach China's territorial waters as a display of its sea power.

The US has now expanded its aircraft carriers' influence to China's Yellow Sea and South China Sea, Su noted.

"Aircraft carriers have already become an important strategic platform for US military intervention," Su said.

Su added that China wants to build aircraft carriers and anti-aircraft carrier missile bases to safeguard its national security.

On Sunday, the US aircraft carrier USS George Washington, which recently took part in military exercises with South Korea, hosted a Vietnamese military delegation in the South China Sea off the Vietnamese port of Danang.

Zhai Dequan, deputy secretary general of the China Arms Control and Disarmament Association, said that as China's economy develops, it is also necessary for China to develop its national defense.

Zhai pointed out that such actions are not directed at any country or bloc of countries.
Wang Haishan contributed to this story.

The world's largest human domino, comprising of 10,267 people, was formed on the grasslands in Ordos, the Inner Mongolia autonomous region, on Thursday, toppling a Guinness World Record created a decade ago.

The people were divided into more than 50 groups to form the word Ordos both in Chinese and English.

In a human domino, the person standing first falls backward, causing the row of people behind him to fall one after another. It took an hour for the domino to complete.

"This magnificent feat was very hard to achieve, but we were all confident we would rewrite history," said Liu Manshan, who was in charge of the event and head of the culture bureau of Ordos' Dongsheng district.

The last Guinness World Record of the largest human domino was created by 9,234 students in Singapore in 2000.

Rehabilitation is a broad term that summarizes all medical procedures and / or addiction treatment of psychoactive substances such as alcohol, drugs, nicotine, or drugs such as heroin, cocaine and amphetamines. The goal of drug rehab is to convince the addict to stop consumption of psychoactive substances, especially to avoid problems arising from excessive use of these substances. People of all ages suffer from drug addiction: babies who were parentally exposed to drugs, teens, adults, parents. Many people are in the social circumstances of financial difficulty making drug treatment addiction to be more cumbersome. Although some problems are common to all groups of people, addiction severity varies from person to person. Drug addiction is a disease that can be treated because it is regarded as a disease. Treatment generally is not one but must be tailored according to each person.

Addiction is defined as a chronic and recurrent brain is characterized by obsessive search of drugs and their consumption. Addiction is seen as a brain disease because drugs can change brain structure and its working nature. Drug may have prolonged effects on the brain resulting in dangerous behaviors that can be seen in addicts. The best solution to get out of the problem is to get admitted in an alcohol treatment center.

Treatment of drug and alcohol addicts takes into account the two facts of addiction: physical and psychological dependence. Research shows that combining the drug with the behavioral treatment is the best method of alcohol rehab and addiction treatment. Physical dependence alcohol treatment involves a detoxification process to help the patient to withstand adverse reactions occurring after discontinuation of drug.